The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

Amino acids signal to the mTOR complex I (mTORC1) growth pathway through the Rag GTPases. Multiple distinct complexes regulate the Rags, including GATOR1, a GTPase activating protein (GAP), and GATOR2, a positive regulator of unknown molecular function. Arginine stimulation of cells activates mTORC1...

Full description

Bibliographic Details
Main Authors: Gygi, Melanie P., Shen, Kuang, Harper, J. Wade, Gygi, Steven P., Chantranupong, Lynne, Scaria, Sonia M., Saxton, Robert Andrew, Wyant, Gregory Andrew, Wang, Tim, Sabatini, David
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/108635
https://orcid.org/0000-0001-9388-1633
https://orcid.org/0000-0002-9376-3984
https://orcid.org/0000-0003-4642-3706
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-1446-7256

Internet

http://hdl.handle.net/1721.1/108635
https://orcid.org/0000-0001-9388-1633
https://orcid.org/0000-0002-9376-3984
https://orcid.org/0000-0003-4642-3706
https://orcid.org/0000-0002-4227-5163
https://orcid.org/0000-0002-1446-7256

Similar Items