Interfacial binding and aggregation of lamin A tail domains associated with Hutchinson–Gilford progeria syndrome

Interfacial binding and aggregation of lamin A tail domains associated with Hutchinson–Gilford progeria syndrome

Hutchinson–Gilford progeria syndrome is a premature aging disorder associated with the expression of ∆50 lamin A (∆50LA), a mutant form of the nuclear structural protein lamin A (LA). ∆50LA is missing 50 amino acids from the tail domain and retains a C-terminal farnesyl group that is cleaved from th...

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Bibliographic Details
Main Authors: Kalinowski, Agnieszka, Yaron, Peter N., Qin, Zhao, Shenoy, Siddharth, Dahl, Kris Noel, Buehler, Markus J, Loesche, Mathias
Other Authors: Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/108675
https://orcid.org/0000-0002-4173-9659

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http://hdl.handle.net/1721.1/108675
https://orcid.org/0000-0002-4173-9659

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