Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

Inflammasomes are cytosolic caspase-1-activation complexes that sense intrinsic and extrinsic danger signals, and trigger inflammatory responses and pyroptotic cell death. Homotypic interactions among Pyrin domains and caspase recruitment domains (CARDs) in inflammasome-complex components mediate ol...

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Bibliographic Details
Main Authors: Lu, Alvin, Li, Yang, Schmidt, Florian I, Yin, Qian, Chen, Shuobing, Fu, Tian-Min, Tong, Alexander B, Mao, Youdong, Wu, Hao, Ploegh, Hidde
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/108705
https://orcid.org/0000-0002-1090-6071

Internet

http://hdl.handle.net/1721.1/108705
https://orcid.org/0000-0002-1090-6071

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