Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of pyruvate kinase (PK), and PKM2 expression is closely linked to embryogenesis, tissue regeneration, and cancer. To interrogate the functional requirement for PKM2 during development and tissue homeostasis, we generat...

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书目详细资料
Main Authors: Clish, Clary B., Bronson, Roderick T., Dayton, Talya L., Gocheva, Vasilena, Miller, Kathryn, Israelsen, William James, Bhutkar, Arjun, Davidson, Shawn Michael, Luengo, Alba, Jacks, Tyler E., Vander Heiden, Matthew G.
其他作者: Massachusetts Institute of Technology. Department of Biology
格式: 文件
语言:en_US
出版: Cold Spring Harbor Laboratory Press 2017
在线阅读:http://hdl.handle.net/1721.1/108777
https://orcid.org/0000-0002-7994-7963
https://orcid.org/0000-0002-7799-6454
https://orcid.org/0000-0003-0701-5275
https://orcid.org/0000-0002-4236-0229
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0002-6702-4192

因特网

http://hdl.handle.net/1721.1/108777
https://orcid.org/0000-0002-7994-7963
https://orcid.org/0000-0002-7799-6454
https://orcid.org/0000-0003-0701-5275
https://orcid.org/0000-0002-4236-0229
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0002-6702-4192

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