Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination

Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the immune system responds optimally to antigen kinetics most similar to replicating infections, rather than a bolus dose. Usin...

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Bibliographic Details
Main Authors: Hu, Joyce K., Crampton, Jordan, Sanders, Rogier W., Moore, John P., Crotty, Shane, Tam, Hok Hei, Melo, Mariane Bandeira, Kang, Myung Sun, Pelet, Jeisa, Ruda, Vera, Foley, Maria Hottelet, Kumari, Sudha, Baldeon, Alexis D, Langer, Robert S, Anderson, Daniel Griffith, Chakraborty, Arup K, Irvine, Darrell J
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2017
Online Access:http://hdl.handle.net/1721.1/108787
https://orcid.org/0000-0002-2358-0330
https://orcid.org/0000-0002-8800-3438
https://orcid.org/0000-0003-2705-7245
https://orcid.org/0000-0003-4255-0492
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-1268-9602

Internet

http://hdl.handle.net/1721.1/108787
https://orcid.org/0000-0002-2358-0330
https://orcid.org/0000-0002-8800-3438
https://orcid.org/0000-0003-2705-7245
https://orcid.org/0000-0003-4255-0492
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-1268-9602

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