Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination
Natural infections expose the immune system to escalating antigen and inflammation over days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the immune system responds optimally to antigen kinetics most similar to replicating infections, rather than a bolus dose. Usin...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
National Academy of Sciences (U.S.)
2017
|
| Online Access: | http://hdl.handle.net/1721.1/108787 https://orcid.org/0000-0002-2358-0330 https://orcid.org/0000-0002-8800-3438 https://orcid.org/0000-0003-2705-7245 https://orcid.org/0000-0003-4255-0492 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0003-1268-9602 |