Optimal immunization cocktails can promote induction of broadly neutralizing Abs against highly mutable pathogens

Strategies to elicit Abs that can neutralize diverse strains of a highly mutable pathogen are likely to result in a potent vaccine. Broadly neutralizing Abs (bnAbs) against HIV have been isolated from patients, proving that the human immune system can evolve them. Using computer simulations and theo...

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Main Authors: Moore, Penny L., Shaffer, James S, Kardar, Mehran, Chakraborty, Arup K
其他作者: Massachusetts Institute of Technology. Department of Biological Engineering
格式: 文件
语言:en_US
出版: National Academy of Sciences (U.S.) 2017
在线阅读:http://hdl.handle.net/1721.1/108795
https://orcid.org/0000-0002-1124-6124
https://orcid.org/0000-0002-1112-5912
https://orcid.org/0000-0003-1268-9602