A Breast Cancer Stem Cell-Selective, Mammospheres-Potent Osmium(VI) Nitrido Complex

A Breast Cancer Stem Cell-Selective, Mammospheres-Potent Osmium(VI) Nitrido Complex

The effect of a newly developed osmium(VI) nitrido complex, 1, on breast cancer stem cells (CSCs) is reported. The complex displays selective toxicity for HMLER breast cancer cells enriched with CD44-positive, CSC-like cells over the same cells having reduced CSC character. Remarkably, 1 also reduce...

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Bibliographic Details
Main Authors: Suntharalingam, Kogularamanan, Lin, Wei, Johnstone, Timothy, Bruno, Peter Michael, Zheng, Yaorong, Hemann, Michael, Lippard, Stephen J.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2017
Online Access:http://hdl.handle.net/1721.1/108805
https://orcid.org/0000-0003-3383-0118
https://orcid.org/0000-0002-2693-4982

Internet

http://hdl.handle.net/1721.1/108805
https://orcid.org/0000-0003-3383-0118
https://orcid.org/0000-0002-2693-4982

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