Tracing Dynamic Changes of DNA Methylation at Single-Cell Resolution

Tracing Dynamic Changes of DNA Methylation at Single-Cell Resolution

Mammalian DNA methylation plays an essential role in development. To date, only snapshots of different mouse and human cell types have been generated, providing a static view on DNA methylation. To enable monitoring of methylation status as it changes over time, we establish a reporter of genomic me...

Full description

Bibliographic Details
Main Authors:	Stelzer, Yonatan, Soldner, Frank, Markoulaki, Styliani, Shivalila, Chikdu Shakti, Jaenisch, Rudolf
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	en_US
Published:	Elsevier 2017
Online Access:	http://hdl.handle.net/1721.1/108812 https://orcid.org/0000-0002-2905-0306

Similar Items

Parent-of-Origin DNA Methylation Dynamics during Mouse Development
by: Stelzer, Yonatan, et al.
Published: (2017)

Parent-of-Origin DNA Methylation Dynamics during Mouse Development
by: Yonatan Stelzer, et al.
Published: (2016-09-01)

Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs
by: Song, Yuelin, et al.
Published: (2020)

Technology development in mouse genetics and epigenetics
by: Shivalila, Chikdu Shakti
Published: (2016)

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression
by: Soldner, Frank, et al.
Published: (2017)

JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell–derived neural progenitors and cortical neurons
by: Roessler, Reinhard, et al.
Published: (2020)

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering
by: Yang, Hui, et al.
Published: (2017)

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
by: Wang, Haoyi, et al.
Published: (2016)

Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation
by: Markoulaki, Styliani, et al.
Published: (2018)

Matched Developmental Timing of Donor Cells with the Host Is Crucial for Chimera Formation
by: Malkiel A. Cohen, et al.
Published: (2018-05-01)

TALEN-mediated editing of the mouse Y chromosome
by: Wang, Haoyi, et al.
Published: (2015)

Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation
by: Edupuganti, Raghu Ram, et al.
Published: (2018)

Stem Cells, Genome Editing, and the Path to Translational Medicine
by: Soldner, Frank, et al.
Published: (2020)

In Vitro Modeling of Complex Neurological Diseases
by: Soldner, Frank, et al.
Published: (2020)

Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis
by: Meissner, Alexander, et al.
Published: (2012)

Editing DNA Methylation in the Mammalian Genome
by: Liu, X. Shawn, et al.
Published: (2018)

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
by: Wang, Haoyi, et al.
Published: (2014)

Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation
by: Edupuganti, Raghu Ram, et al.
Published: (2017)

Alternative SET/TAFI Promoters Regulate Embryonic Stem Cell Differentiation
by: Raghu Ram Edupuganti, et al.
Published: (2017-10-01)

Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos
by: Cohen, Malkiel A., et al.
Published: (2017)

Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution
by: Gu, Hongcang, et al.
Published: (2012)

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner
by: Welstead, G. Grant, et al.
Published: (2013)

Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase
by: Buganim, Yosef, et al.
Published: (2014)

Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
by: Papathanasiou, Stamatis, et al.
Published: (2022)

Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing
by: Stamatis Papathanasiou, et al.
Published: (2021-10-01)

scMET: Bayesian modeling of DNA methylation heterogeneity at single-cell resolution
by: Chantriolnt-Andreas Kapourani, et al.
Published: (2021-04-01)

One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation
by: Jacobsen, Johanne T., et al.
Published: (2020)

Investigating Different DNA Methylation Patterns at the Resolution of Methylation Haplotypes
by: Xiaoqing Peng, et al.
Published: (2021-06-01)

High Resolution Imaging of DNA Methylation Dynamics using a Zebrafish Reporter
by: Ranran Zhang, et al.
Published: (2017-07-01)

DNA methylation analysis of chromosome 21 gene promoters at single base pair and single allele resolution.
by: Yingying Zhang, et al.
Published: (2009-03-01)

DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons.
by: Kimberly D Siegmund, et al.
Published: (2007-01-01)

DNA methylation biomarkers in asthma and rhinitis: Are we there yet?
by: Evangelia Legaki, et al.
Published: (2022-03-01)

High-resolution analysis of cytosine methylation in ancient DNA.
by: Bastien Llamas, et al.
Published: (2012-01-01)

Transgene Excision Has No Impact on In Vivo Integration of Human iPS Derived Neural Precursors
by: Major, Tamara, et al.
Published: (2012)

Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer
by: Steine, Eveline J., et al.
Published: (2012)

In situ genome sequencing resolves DNA sequence and structure in intact biological samples
by: Payne, Andrew C, et al.
Published: (2022)

In situ genome sequencing resolves DNA sequence and structure in intact biological samples
by: Payne, Andrew C, et al.
Published: (2021)

Single-cell DNA methylation sequencing by combinatorial indexing and enzymatic DNA methylation conversion
by: Zac Chatterton, et al.
Published: (2023-01-01)

High-Resolution Single-Cell DNA Methylation Measurements Reveal Epigenetically Distinct Hematopoietic Stem Cell Subpopulations
by: Tony Hui, et al.
Published: (2018-08-01)

Transgene excision has no impact on in vivo integration of human iPS derived neural precursors.
by: Tamara Major, et al.
Published: (2011-01-01)