Structural elements of an NRPS cyclization domain and its intermodule docking domain

Structural elements of an NRPS cyclization domain and its intermodule docking domain

Epothilones are thiazole-containing natural products with anticancer activity that are biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) enzymes EpoA–F. A cyclization domain of EpoB (Cy) assembles the thiazole functionality from an acetyl group and l-cysteine via con...

Full description

Bibliographic Details
Main Authors: Dowling, Daniel P., Kung, Yan, Croft, Anna K., Taghizadeh, Koli, Kelly, Wendy L., Walsh, Christopher T., Drennan, Catherine L.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2017
Online Access:http://hdl.handle.net/1721.1/109039
https://orcid.org/0000-0001-5486-2755

Internet

http://hdl.handle.net/1721.1/109039
https://orcid.org/0000-0001-5486-2755

Similar Items