Discovery and Characterization of a Disulfide-Locked C[subscript 2]-Symmetric Defensin Peptide

Discovery and Characterization of a Disulfide-Locked C[subscript 2]-Symmetric Defensin Peptide

We report the discovery of HD5-CD, an unprecedented C[subscript 2]-symmetric β-barrel-like covalent dimer of the cysteine-rich host-defense peptide human defensin 5 (HD5). Dimerization results from intermonomer disulfide exchange between the canonical α-defensin Cys[superscript II]–Cys[superscript I...

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Bibliographic Details
Main Authors: Ziarek, Joshua J., Wagner, Gerhard, Wommack, Andrew, Tomaras, Jill M, Chileveru, Haritha reddy, Zhang, Yunfei, Nolan, Elizabeth Marie
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Chemical Society 2017
Online Access:http://hdl.handle.net/1721.1/109106
https://orcid.org/0000-0002-2515-5901
https://orcid.org/0000-0002-6426-2291
https://orcid.org/0000-0002-6153-8803

Internet

http://hdl.handle.net/1721.1/109106
https://orcid.org/0000-0002-2515-5901
https://orcid.org/0000-0002-6426-2291
https://orcid.org/0000-0002-6153-8803

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