Sensitivity-Enhanced NMR Reveals Alterations in Protein Structure by Cellular Milieus

Biological processes occur in complex environments containing a myriad of potential interactors. Unfortunately, limitations on the sensitivity of biophysical techniques normally restrict structural investigations to purified systems, at concentrations that are orders of magnitude above endogenous le...

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Bibliographic Details
Main Authors: Frederick, Kendra K., Michaelis, Vladimir K., Corzilius, Bjorn, Ong, Ta-Chung, Jacavone, Angela, Griffin, Robert Guy, Lindquist, Susan
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/109144
https://orcid.org/0000-0002-6708-7660
https://orcid.org/0000-0003-1589-832X
https://orcid.org/0000-0003-1307-882X