All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

All-optical electrophysiology—spatially resolved simultaneous optical perturbation and measurement of membrane voltage—would open new vistas in neuroscience research. We evolved two archaerhodopsin-based voltage indicators, QuasAr1 and QuasAr2, which show improved brightness and voltage sensitivity,...

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Bibliographic Details
Main Authors: Hochbaum, Daniel R, Zhao, Yongxin, Farhi, Samouil L, Werley, Christopher A, Kapoor, Vikrant, Zou, Peng, Kralj, Joel M, Maclaurin, Dougal, Smedemark-Margulies, Niklas, Saulnier, Jessica L, Boulting, Gabriella L, Straub, Christoph, Melkonian, Michael, Wong, Gane Ka-Shu, Harrison, D Jed, Murthy, Venkatesh N, Sabatini, Bernardo L, Campbell, Robert E, Cohen, Adam E, Klapoetke, Nathan Cao, Cho, Yongku, Boyden, Edward
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/109291
https://orcid.org/0000-0002-0419-3351

Internet

http://hdl.handle.net/1721.1/109291
https://orcid.org/0000-0002-0419-3351

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