Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents
The following work describes the development of a novel noninvasive transmucosal drug delivery system, the chitosan sponge matrix (CSM). It is composed of cationic chitosan (CS) nanoparticles (NPs) that encapsulate cisplatin (CDDP) embedded within a polymeric mucoadhesive CS matrix. CSM is designed...
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| פורמט: | Article |
| שפה: | en_US |
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ASME International
2017
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| גישה מקוונת: | http://hdl.handle.net/1721.1/109416 https://orcid.org/0000-0002-6432-1124 https://orcid.org/0000-0003-3884-8376 https://orcid.org/0000-0003-1992-6164 https://orcid.org/0000-0002-6969-4309 https://orcid.org/0000-0003-1204-7570 https://orcid.org/0000-0003-4255-0492 |
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| author | Powell, Geralle Chen, Julie Goldberg, Manijeh Nazari Manzi, Aaron Aydin, Erkin Singh, Gurtej Khoshkenar, Payam Birdi, Amritpreet Kaur LaPorte, Brandon Krauskopf, Alejandro A. Langer, Robert S |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Powell, Geralle Chen, Julie Goldberg, Manijeh Nazari Manzi, Aaron Aydin, Erkin Singh, Gurtej Khoshkenar, Payam Birdi, Amritpreet Kaur LaPorte, Brandon Krauskopf, Alejandro A. Langer, Robert S |
| author_sort | Powell, Geralle |
| collection | MIT |
| description | The following work describes the development of a novel noninvasive transmucosal drug delivery system, the chitosan sponge matrix (CSM). It is composed of cationic chitosan (CS) nanoparticles (NPs) that encapsulate cisplatin (CDDP) embedded within a polymeric mucoadhesive CS matrix. CSM is designed to swell up when exposed to moisture, facilitating release of the NPs via diffusion across the matrix. CSM is intended to be administered topically and locally to mucosal tissues, with its initial indication being oral cancer (OC). Currently, intravenous (IV) administered CDDP is the gold standard chemotherapeutic agent used in the treatment of OC. However, its clinical use has been limited by its renal and hemotoxicity profile. We aim to locally administer CDDP via encapsulation in CS NPs and deliver them directly to the oral cavity with CSM. It is hypothesized that such a delivery device will greatly reduce any systemic toxicity and increase antitumor efficacy. This paper describes the methods for developing CSM and maintaining the integrity of CDDP NPs embedded in the CSM. |
| first_indexed | 2024-09-23T12:58:06Z |
| format | Article |
| id | mit-1721.1/109416 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:58:06Z |
| publishDate | 2017 |
| publisher | ASME International |
| record_format | dspace |
| spelling | mit-1721.1/1094162022-09-28T11:14:31Z Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents Powell, Geralle Chen, Julie Goldberg, Manijeh Nazari Manzi, Aaron Aydin, Erkin Singh, Gurtej Khoshkenar, Payam Birdi, Amritpreet Kaur LaPorte, Brandon Krauskopf, Alejandro A. Langer, Robert S Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Goldberg, Manijeh Nazari Manzi, Aaron Aydin, Erkin Singh, Gurtej Khoshkenar, Payam Birdi, Amritpreet Kaur LaPorte, Brandon Krauskopf, Alejandro A. Langer, Robert S The following work describes the development of a novel noninvasive transmucosal drug delivery system, the chitosan sponge matrix (CSM). It is composed of cationic chitosan (CS) nanoparticles (NPs) that encapsulate cisplatin (CDDP) embedded within a polymeric mucoadhesive CS matrix. CSM is designed to swell up when exposed to moisture, facilitating release of the NPs via diffusion across the matrix. CSM is intended to be administered topically and locally to mucosal tissues, with its initial indication being oral cancer (OC). Currently, intravenous (IV) administered CDDP is the gold standard chemotherapeutic agent used in the treatment of OC. However, its clinical use has been limited by its renal and hemotoxicity profile. We aim to locally administer CDDP via encapsulation in CS NPs and deliver them directly to the oral cavity with CSM. It is hypothesized that such a delivery device will greatly reduce any systemic toxicity and increase antitumor efficacy. This paper describes the methods for developing CSM and maintaining the integrity of CDDP NPs embedded in the CSM. 2017-05-30T15:58:11Z 2017-05-30T15:58:11Z 2015-07 2015-06 Article http://purl.org/eprint/type/JournalArticle 1949-2944 http://hdl.handle.net/1721.1/109416 Goldberg, Manijeh; Manzi, Aaron; Aydin, Erkin; Singh, Gurtej; Khoshkenar, Payam; Birdi, Amritpreet; LaPorte, Brandon et al. “Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents.” Journal of Nanotechnology in Engineering and Medicine 5, no. 4 (November 2014): 040905_1- 040905_11 © 2014 ASME https://orcid.org/0000-0002-6432-1124 https://orcid.org/0000-0003-3884-8376 https://orcid.org/0000-0003-1992-6164 https://orcid.org/0000-0002-6969-4309 https://orcid.org/0000-0003-1204-7570 https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.1115/1.4030899 Journal of Nanotechnology in Engineering and Medicine Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf ASME International American Society of Mechanical Engineers (ASME) |
| spellingShingle | Powell, Geralle Chen, Julie Goldberg, Manijeh Nazari Manzi, Aaron Aydin, Erkin Singh, Gurtej Khoshkenar, Payam Birdi, Amritpreet Kaur LaPorte, Brandon Krauskopf, Alejandro A. Langer, Robert S Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents |
| title | Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents |
| title_full | Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents |
| title_fullStr | Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents |
| title_full_unstemmed | Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents |
| title_short | Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents |
| title_sort | development of a nanoparticle embedded chitosan sponge for topical and local administration of chemotherapeutic agents |
| url | http://hdl.handle.net/1721.1/109416 https://orcid.org/0000-0002-6432-1124 https://orcid.org/0000-0003-3884-8376 https://orcid.org/0000-0003-1992-6164 https://orcid.org/0000-0002-6969-4309 https://orcid.org/0000-0003-1204-7570 https://orcid.org/0000-0003-4255-0492 |
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