Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents
The following work describes the development of a novel noninvasive transmucosal drug delivery system, the chitosan sponge matrix (CSM). It is composed of cationic chitosan (CS) nanoparticles (NPs) that encapsulate cisplatin (CDDP) embedded within a polymeric mucoadhesive CS matrix. CSM is designed...
Main Authors: | Powell, Geralle, Chen, Julie, Goldberg, Manijeh Nazari, Manzi, Aaron, Aydin, Erkin, Singh, Gurtej, Khoshkenar, Payam, Birdi, Amritpreet Kaur, LaPorte, Brandon, Krauskopf, Alejandro A., Langer, Robert S |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemical Engineering |
Format: | Article |
Language: | en_US |
Published: |
ASME International
2017
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Online Access: | http://hdl.handle.net/1721.1/109416 https://orcid.org/0000-0002-6432-1124 https://orcid.org/0000-0003-3884-8376 https://orcid.org/0000-0003-1992-6164 https://orcid.org/0000-0002-6969-4309 https://orcid.org/0000-0003-1204-7570 https://orcid.org/0000-0003-4255-0492 |
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