A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity

A rare schizophrenia risk variant of CACNA1I disrupts CaV3.3 channel activity

CACNA1I is a candidate schizophrenia risk gene. It encodes the pore-forming human CaV3.3 α1 subunit, a subtype of voltage-gated calcium channel that contributes to T-type currents. Recently, two de novo missense variations, T797M and R1346H, of hCaV3.3 were identified in individuals with schizophren...

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Bibliographic Details
Main Authors: Andrade, A., Lipscombe, D., Hope, Jennifer M., Allen, Alexander, Yorgan, Valerie A, Pan, Jennifer Q.
Other Authors: Massachusetts Institute of Technology. Department of Architecture
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/109441

Internet

http://hdl.handle.net/1721.1/109441

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