The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection
Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit high variation in terms of quality, as measured in mice by chimera contribution and tetraploid complementation. Reliab...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | en_US |
Published: |
Elsevier
2017
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Online Access: | http://hdl.handle.net/1721.1/109508 https://orcid.org/0000-0001-8855-8647 |