The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection

The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection

Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit high variation in terms of quality, as measured in mice by chimera contribution and tetraploid complementation. Reliab...

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Main Authors: Buganim, Yosef, Markoulaki, Styliani, van Wietmarschen, Niek, Wu, Tao, Ganz, Kibibi, Akhtar-Zaidi, Batool, He, Yupeng, Abraham, Brian J., Porubsky, David, Kulenkampff, Elisabeth, Shi, Linyu, Gao, Qing, Sarkar, Sovan, Cohen, Malkiel, Goldmann, Johanna, Nery, Joseph R., Schultz, Matthew D., Ecker, Joseph R., Xiao, Andrew, Lansdorp, Peter M., Hoke, Heather Ashley, Jaenisch, Rudolf, Faddah, Dina A., Young, Richard A.
其他作者: Massachusetts Institute of Technology. Department of Biology
格式: 文件
语言:en_US
出版: Elsevier 2017
在线阅读:http://hdl.handle.net/1721.1/109508
https://orcid.org/0000-0001-8855-8647

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http://hdl.handle.net/1721.1/109508
https://orcid.org/0000-0001-8855-8647

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