The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection

The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection

Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4, Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit high variation in terms of quality, as measured in mice by chimera contribution and tetraploid complementation. Reliab...

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Bibliographic Details
Main Authors: Buganim, Yosef, Markoulaki, Styliani, van Wietmarschen, Niek, Wu, Tao, Ganz, Kibibi, Akhtar-Zaidi, Batool, He, Yupeng, Abraham, Brian J., Porubsky, David, Kulenkampff, Elisabeth, Shi, Linyu, Gao, Qing, Sarkar, Sovan, Cohen, Malkiel, Goldmann, Johanna, Nery, Joseph R., Schultz, Matthew D., Ecker, Joseph R., Xiao, Andrew, Lansdorp, Peter M., Hoke, Heather Ashley, Jaenisch, Rudolf, Faddah, Dina A., Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/109508
https://orcid.org/0000-0001-8855-8647

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