Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

Oncogenes such as K‐ras mediate cellular and metabolic transformation during tumorigenesis. To analyze K‐Ras‐dependent metabolic alterations, we employed [superscript 13]C metabolic flux analysis (MFA), non‐targeted tracer fate detection (NTFD) of [superscript 15]N‐labeled glutamine, and transcripto...

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Bibliographic Details
Main Authors: Danna, L. S., Balestrieri, C., Alberghina, L., Chiaradonna, F., Gaglio, Daniela, Metallo, Christian M., Da Costa Gameiro Guerreiro, Paulo, Hiller, Karsten, Stephanopoulos, Gregory
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/109766
https://orcid.org/0000-0001-6909-4568

Internet

http://hdl.handle.net/1721.1/109766
https://orcid.org/0000-0001-6909-4568

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