Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

Oncogenes such as K‐ras mediate cellular and metabolic transformation during tumorigenesis. To analyze K‐Ras‐dependent metabolic alterations, we employed [superscript 13]C metabolic flux analysis (MFA), non‐targeted tracer fate detection (NTFD) of [superscript 15]N‐labeled glutamine, and transcripto...

Full description

Bibliographic Details
Main Authors:	Danna, L. S., Balestrieri, C., Alberghina, L., Chiaradonna, F., Gaglio, Daniela, Metallo, Christian M., Da Costa Gameiro Guerreiro, Paulo, Hiller, Karsten, Stephanopoulos, Gregory
Other Authors:	Massachusetts Institute of Technology. Department of Chemical Engineering
Format:	Article
Language:	en_US
Published:	Nature Publishing Group 2017
Online Access:	http://hdl.handle.net/1721.1/109766 https://orcid.org/0000-0001-6909-4568

Similar Items

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
by: Metallo, Christian M., et al.
Published: (2014)

The Role of Wild-Type RAS in Oncogenic RAS Transformation
by: Erin Sheffels, et al.
Published: (2021-04-01)

Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer
by: Rui Ni, et al.
Published: (2023-03-01)

Malignant transformation by oncogenic K‐ras requires IDH2‐mediated reductive carboxylation to promote glutamine utilization
by: Rui Liu, et al.
Published: (2023-02-01)

RAS oncogenes direct metastasis
by: Magda Spella, et al.
Published: (2017-09-01)

RAS: Striking at the Core of the Oncogenic Circuitry
by: Ryan C. Gimple, et al.
Published: (2019-09-01)

Glutamine addiction in tumor cell: oncogene regulation and clinical treatment
by: Xian Li, et al.
Published: (2024-01-01)

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras
by: Friedlander, Sharon Y. Gidekel, et al.
Published: (2015)

NTFD--a stand-alone application for the non-targeted detection of stable isotope-labeled compounds in GC/MS data
by: Kelleher, Joanne Keene, et al.
Published: (2014)

Autophagic activity dictates the cellular response to oncogenic RAS.
by: Wang, Y, et al.
Published: (2012)

Editorial: Oncogenic RAS-Dependent Reprogramming of Cellular Plasticity
by: Georgia Konstantinidou, et al.
Published: (2020-04-01)

Protein-based Degrader Strategies against Oncogenic RAS
by: Cheah, Keith M.
Published: (2023)

In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation
by: Gameiro, Paulo A., et al.
Published: (2016)

Neuroblastoma RAS viral oncogene homolog (N-RAS) deficiency aggravates liver injury and fibrosis
by: Kang Zheng, et al.
Published: (2023-08-01)

Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism
by: Fendt, Sarah-Maria, et al.
Published: (2014)

The ancestral type of the R-RAS protein has oncogenic potential
by: Antea Talajić, et al.
Published: (2024-02-01)

BRCA1 Partially Reverses the Transforming Activity of the ras Oncogene
by: Abhay Kumar, et al.
Published: (1999-11-01)

Pharmacological modulation of oncogenic Ras by natural products and their derivatives: renewed hope in the discovery of novel anti-Ras drugs
by: Quah, Shun Ying, et al.
Published: (2016)

Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway
by: Taryn E Gillies, et al.
Published: (2020-10-01)

Hidden Targets in RAF Signalling Pathways to Block Oncogenic RAS Signalling
by: Aoife A. Nolan, et al.
Published: (2021-04-01)

RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma
by: Philip East, et al.
Published: (2022-09-01)

Optimization of [superscript 13]C isotopic tracers for metabolic flux analysis in mammalian cells
by: Walther, Jason L., et al.
Published: (2015)

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
by: Hocker, Harrison J., et al.
Published: (2013)

Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition
by: Antonella Catalano, et al.
Published: (2021-04-01)

Targeting immunosuppression in the tumor microenvironment and protein-based antagonism of oncogenic K-Ras
by: Kauke, Monique Jacqueline
Published: (2018)

Concurrent mutation in exons 1 and 2 of the K-ras oncogene in colorectal cancer
by: Fiorella Guadagni, et al.
Published: (2012-01-01)

Investigation on the hybridoma cell requirement of glucose and glutamine concentration for growth
by: Saifuddin , Baharuddin
Published: (2013)

Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines.
by: Bernhard, E, et al.
Published: (2000)

Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.
by: Cengel, K, et al.
Published: (2007)

Autophagy Is Polarized toward Cell Front during Migration and Spatially Perturbed by Oncogenic Ras
by: Manish Kumar Singh, et al.
Published: (2021-10-01)

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras
by: Yu, Haiyan, et al.
Published: (2018)

Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.
by: Phuoc T Tran, et al.
Published: (2008-05-01)

Pharmacological or genetic inhibition of hypoxia signaling attenuates oncogenic RAS-induced cancer phenotypes
by: Jun-yi Zhu, et al.
Published: (2022-02-01)

Patterning of oncogenic Ras clustering in live cells using vertically aligned nanostructure arrays
by: Mu, Huanwen, et al.
Published: (2022)

Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine
by: Cetinbas, Naniye Mallı, et al.
Published: (2017)

Abrogation of oncogenic k-ras function by andrographolide derivatives via in silico, in vitro, and in vivo approaches
by: Quah, Shun Ying
Published: (2021)

Tissue-specific p19[superscript Arf] regulation dictates the response to oncogenic K-ras
by: Young, Nathan P., et al.
Published: (2014)

ST2 gene products critically contribute to cellular transformation caused by an oncogenic Ras mutant
by: Kenji Tago, et al.
Published: (2017-10-01)

Advancing Cancer Treatment by Targeting Glutamine Metabolism—A Roadmap
by: Anna Halama, et al.
Published: (2022-01-01)

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
by: Fendt, Sarah-Maria, et al.
Published: (2014)