Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations

Recent drug discovery and development efforts have created a large arsenal of targeted and chemotherapeutic drugs for precision medicine. However, drug resistance remains a major challenge as minor pre-existing resistant subpopulations are often found to be enriched at relapse. Current drug design h...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Sun, Daphne S., Dalin, Simona, Hemann, Michael, Lauffenburger, Douglas A, Zhao, Boyang
Kolejni autorzy: Koch Institute for Integrative Cancer Research at MIT
Format: Artykuł
Język:en_US
Wydane: Nature Publishing Group 2017
Dostęp online:http://hdl.handle.net/1721.1/109785
https://orcid.org/0000-0001-5024-9718
https://orcid.org/0000-0003-4610-1707