Differential selective pressure alters rate of drug resistance acquisition in heterogeneous tumor populations
Recent drug discovery and development efforts have created a large arsenal of targeted and chemotherapeutic drugs for precision medicine. However, drug resistance remains a major challenge as minor pre-existing resistant subpopulations are often found to be enriched at relapse. Current drug design h...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/109785 https://orcid.org/0000-0001-5024-9718 https://orcid.org/0000-0003-4610-1707 |