Solid-phase synthesis provides a modular, lysine-based platform for fluorescent discrimination of nitroxyl and biological thiols

We describe a modular, synthetically facile solid-phase approach aimed at separating the fluorescent reporter and binding unit of small-molecule metal-based sensors. The first representatives contain a lysine backbone functionalized with a tetramethylrhodamine fluorophore, and they operate by modula...

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Bibliographic Details
Main Authors: Loas, Andrei Ioan, Radford, Robert John, Liang, Alexandria D, Lippard, Stephen J.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: Royal Society of Chemistry (RSC) 2017
Online Access:http://hdl.handle.net/1721.1/109819
https://orcid.org/0000-0002-9269-7815
https://orcid.org/0000-0002-2693-4982