Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

Checkpoint blockade with antibodies specific for cytotoxic T lymphocyte–associated protein (CTLA)-4 or programmed cell death 1 (PDCD1; also known as PD-1) elicits durable tumor regression in metastatic cancer, but these dramatic responses are confined to a minority of patients. This suboptimal outco...

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Bibliographic Details
Main Authors:	Cochran, Jennifer R, Moynihan, Kelly Dare, Opel, Cary Francis, Szeto, Gregory, Tzeng, Alice, Zhu, Eric Franklin, Engreitz, Jesse Michael, Williams, Robert T., Rakhra, Kavya, Zhang, Michael H, Rothschilds, Adrienne Marie, Kumari, Sudha, Kelly, Ryan Lewis, Kwan, Byron Hua, Abraham, Wuhbet, Hu, Kevin, Mehta, Naveen, Kauke, Monique Jacqueline, Suh, Heikyung, Lauffenburger, Douglas A, Wittrup, Karl Dane, Irvine, Darrell J
Other Authors:	Broad Institute of MIT and Harvard
Format:	Article
Language:	en_US
Published:	Nature Publishing Group 2017
Online Access:	http://hdl.handle.net/1721.1/109826 https://orcid.org/0000-0001-7604-1333 https://orcid.org/0000-0001-7316-6923 https://orcid.org/0000-0003-3789-1516 https://orcid.org/0000-0002-5754-1719 https://orcid.org/0000-0003-2371-0470 https://orcid.org/0000-0002-4772-4570 https://orcid.org/0000-0003-2705-7245 https://orcid.org/0000-0001-5003-9104 https://orcid.org/0000-0002-9851-7029 https://orcid.org/0000-0003-3480-6750 https://orcid.org/0000-0002-0013-3941 https://orcid.org/0000-0003-0787-298X https://orcid.org/0000-0003-2398-5896

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Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

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