Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits

Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits

Autism spectrum disorder (ASD) is a heterogeneous disease, but genetically defined models can provide an entry point to studying the molecular underpinnings of this disorder. We generated germline mutant mice with loss-of-function mutations in Chd8, a de novo mutation strongly associated with ASD, a...

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Bibliographic Details
Main Authors: Shetty, Ashwin S., Weisbach, Niels R., Crabtree, Gerald R., Platt, Randall Jeffrey, Zhou, Yang, Slaymaker, Ian, Kim, Jinah, Sharma, Jitendra, Desai, Mitul, Sood, Sabina, Kempton, Hannah R., Feng, Guoping, Zhang, Feng
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/109830
https://orcid.org/0000-0001-8794-2137
https://orcid.org/0000-0002-2196-8737
https://orcid.org/0000-0002-7472-5480
https://orcid.org/0000-0002-8021-277X
https://orcid.org/0000-0003-2782-2509

Internet

http://hdl.handle.net/1721.1/109830
https://orcid.org/0000-0001-8794-2137
https://orcid.org/0000-0002-2196-8737
https://orcid.org/0000-0002-7472-5480
https://orcid.org/0000-0002-8021-277X
https://orcid.org/0000-0003-2782-2509

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