Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability

Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context of particular copy-number alterations (copy-number...

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Bibliographic Details
Main Authors: Paolella, Brenton R, Urbanski, Laura M, Alberta, John A, Bandopadhayay, Pratiti, Nichols, Caitlin A, Agarwalla, Pankaj K, Brown, Meredith S, Lamothe, Rebecca, Yu, Yong, Choi, Peter S, Obeng, Esther A, Heckl, Dirk, Vazquez, Francisca, Buhrlage, Sara J, Stiles, Charles D, Reed, Robin, Gibson, William J, Zack, Travis Ian, Wei, Guo, Wang, Belinda, Tsherniak, Aviad, Weir, Barbara A, Root, David, Cowley, Glenn S, Ebert, Benjamin L, Hahn, William, Beroukhim, Rameen
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: eLife Sciences Publications, Ltd. 2017
Online Access:http://hdl.handle.net/1721.1/109875
https://orcid.org/0000-0003-3159-8175
https://orcid.org/0000-0001-5367-2546

Internet

http://hdl.handle.net/1721.1/109875
https://orcid.org/0000-0003-3159-8175
https://orcid.org/0000-0001-5367-2546

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