Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

Treatment of BRAF‐mutant melanomas with MAP kinase pathway inhibitors is paradigmatic of the promise of precision cancer therapy but also highlights problems with drug resistance that limit patient benefit. We use live‐cell imaging, single‐cell analysis, and molecular profiling to show that exposure...

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Bibliographic Details
Main Authors: Becker, Verena, Izar, Benjamin, Baker, Gregory J, Lin, Jia?Ren, Boswell, Sarah A, Shah, Parin, Rotem, Asaf, Sorger, Peter K, Fallahi-Sichani, Mohammad, Garraway, Levi
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/109938

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http://hdl.handle.net/1721.1/109938

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