Patient-specific modeling of individual sickle cell behavior under transient hypoxia

Sickle cell disease (SCD) is a highly complex genetic blood disorder in which red blood cells (RBC) exhibit heterogeneous morphology changes and decreased deformability. We employ a kinetic model for cell morphological sickling that invokes parameters derived from patient-specific data. This model i...

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Bibliographic Details
Main Authors: Li, Xuejin, Suresh, Subra, Karniadakis, George Em, Du, E, Dao, Ming
Other Authors: Massachusetts Institute of Technology. Department of Materials Science and Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2017
Online Access:http://hdl.handle.net/1721.1/109945
https://orcid.org/0000-0002-0301-0891