Programmable RNA-binding protein composed of repeats of a single modular unit

The ability to monitor and perturb RNAs in living cells would benefit greatly from a modular protein architecture that targets unmodified RNA sequences in a programmable way. We report that the RNA-binding protein PumHD (Pumilio homology domain), which has been widely used in native and modified for...

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Bibliographic Details
Main Authors: Adamala, Katarzyna, Martin Alarcon, Daniel Alberto, Boyden, Edward
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2017
Online Access:http://hdl.handle.net/1721.1/109966
https://orcid.org/0000-0003-0547-8129
https://orcid.org/0000-0002-0419-3351