Small genomic insertions form enhancers that misregulate oncogenes

Small genomic insertions form enhancers that misregulate oncogenes

The non-coding regions of tumour cell genomes harbour a considerable fraction of total DNA sequence variation, but the functional contribution of these variants to tumorigenesis is ill-defined. Among these non-coding variants, somatic insertions are among the least well characterized due to challeng...

Full description

Bibliographic Details
Main Authors: Hnisz, Denes, Li, Zhaodong, Weichert-Leahey, Nina, Rahman, Sunniyat, Liu, Yu, Etchin, Julia, Li, Benshang, Shen, Shuhong, Zhang, Jinghui, Look, A. Thomas, Mansour, Marc R., Abraham, Brian Joseph, Weintraub, Abraham Selby, Kwiatkowski, Nick, Li, Charles Han, Lee, Tong Ihn, Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/110068
https://orcid.org/0000-0003-0998-9882
https://orcid.org/0000-0001-8091-6112
https://orcid.org/0000-0001-8855-8647

Internet

http://hdl.handle.net/1721.1/110068
https://orcid.org/0000-0003-0998-9882
https://orcid.org/0000-0001-8091-6112
https://orcid.org/0000-0001-8855-8647

Similar Items