Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

How disease-associated mutations impair protein activities in the context of biological networks remains mostly undetermined. Although a few renowned alleles are well characterized, functional information is missing for over 100,000 disease-associated variants. Here we functionally profile several t...

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Bibliographic Details
Main Authors: Peng, Jian, Tucker, George Jay, Leighton, Alexander T., Berger Leighton, Bonnie
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/110189
https://orcid.org/0000-0002-2724-7228

Internet

http://hdl.handle.net/1721.1/110189
https://orcid.org/0000-0002-2724-7228

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