A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ

A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ

The eight-subunit T cell receptor (TCR)-CD3 complex is the primary determinant for T cell fate decisions. Yet how it relays ligand-specific information across the cell membrane for conversion to chemical signals remains unresolved. We hypothesized that TCR engagement triggers a change in the spatial...

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Detalles Bibliográficos
Main Authors: Lee, Mark S., Glassman, Caleb R., Deshpande, Neha R., Badgandi, Hemant B., Parrish, Heather L., Kuhns, Michael S., Uttamapinant, Chayasith, Stawski, Philipp Sebastian, Ting, Alice Y
Outros autores: Massachusetts Institute of Technology. Department of Chemistry
Formato: Artigo
Idioma:en_US
Publicado: Elsevier 2017
Acceso en liña:http://hdl.handle.net/1721.1/110270
https://orcid.org/0000-0003-1729-9873
https://orcid.org/0000-0002-8277-5226

Internet

http://hdl.handle.net/1721.1/110270
https://orcid.org/0000-0003-1729-9873
https://orcid.org/0000-0002-8277-5226

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