A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

Finding the components of cellular circuits and determining their functions systematically remains a major challenge in mammalian cells. Here, we introduced genome-wide pooled CRISPR-Cas9 libraries into dendritic cells (DCs) to identify genes that control the induction of tumor necrosis factor (Tnf)...

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Bibliographic Details
Main Authors: Parnas, Oren, Jovanovic, Marko, Eisenhaure, Thomas M., Herbst, Rebecca H., Ye, Chun Jimmie, Przybylski, Dariusz, Tirosh, Itay, Satija, Rahul, Raychowdhury, Raktima, Mertins, Philipp, Carr, Steven A., Hacohen, Nir, Regev, Aviv, Dixit, Atray C., Platt, Randall Jeffrey, Sanjana, Neville E, Shalem, Ophir, Zhang, Feng
Other Authors: Institute for Medical Engineering and Science
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/110389
https://orcid.org/0000-0003-2193-9001
https://orcid.org/0000-0003-2782-2509

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