Regulation of mTORC1 by amino acids
The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular and organismal growth, and hyperactivation of this pathway is implicated in the pathogenesis of many human diseases including cancer and diabetes. mTORC1 promotes growth in response to the availability of nutri...
Main Authors: | Bar-Peled, Liron, Sabatini, David |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Elsevier
2017
|
Online Access: | http://hdl.handle.net/1721.1/110392 https://orcid.org/0000-0002-1446-7256 |
Similar Items
-
Amino acid regulation of mTORC1
by: Bar-Peled, Liron
Published: (2014) -
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
by: Bar-Peled, Liron, et al.
Published: (2014) -
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
by: Sancak, Yasemin, et al.
Published: (2012) -
Rag proteins regulate amino-acid-induced mTORC1 signalling
by: Sancak, Yasemin, et al.
Published: (2011) -
The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
by: Chantranupong, Lynne, et al.
Published: (2015)