Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21

Hepatic SIRT1 Attenuates Hepatic Steatosis and Controls Energy Balance in Mice by Inducing Fibroblast Growth Factor 21

Background & Aims The hepatocyte-derived hormone fibroblast growth factor 21 (FGF21) is a hormone-like regulator of metabolism. The nicotinamide adenine dinucleotide–dependent deacetylase SIRT1 regulates fatty acid metabolism through multiple nutrient sensors. Hepatic overexpression of SIRT1...

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Bibliographic Details
Main Authors: Li, Yu, Wong, Kimberly, Giles, Amber, Jiang, Jianwei, Lee, Jong Woo, Adams, Andrew C., Kharitonenkov, Alexei, Yang, Qin, Gao, Bin, Zang, Mengwei, Guarente, Leonard Pershing
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/110406
https://orcid.org/0000-0003-4064-2510

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http://hdl.handle.net/1721.1/110406
https://orcid.org/0000-0003-4064-2510

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