Necroptosis-Inducing Rhenium(V) Oxo Complexes
Rhenium(V) oxo complexes of general formula [ReO(OMe)(N^N)Cl₂], where N^N = 4,7-diphenyl-1,10-phenanthroline, 1, or 3,4,7,8-tetramethyl-1,10-phenanthroline, 2, effectively kill cancer cells by triggering necroptosis, a non-apoptotic form of cell death. Both complexes evoke necrosome (RIP1-RIP3)-depe...
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| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2017
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| Online Access: | http://hdl.handle.net/1721.1/110417 https://orcid.org/0000-0002-6958-3991 https://orcid.org/0000-0003-3383-0118 https://orcid.org/0000-0002-9192-6858 https://orcid.org/0000-0002-2693-4982 |
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| author | Suntharalingam, Kogularamanan Awuah, Samuel Bruno, Peter Michael Johnstone, Timothy Wang, Fang Lin, Wei Zheng, Yaorong Page, Julia E. Hemann, Michael Lippard, Stephen J. |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Suntharalingam, Kogularamanan Awuah, Samuel Bruno, Peter Michael Johnstone, Timothy Wang, Fang Lin, Wei Zheng, Yaorong Page, Julia E. Hemann, Michael Lippard, Stephen J. |
| author_sort | Suntharalingam, Kogularamanan |
| collection | MIT |
| description | Rhenium(V) oxo complexes of general formula [ReO(OMe)(N^N)Cl₂], where N^N = 4,7-diphenyl-1,10-phenanthroline, 1, or 3,4,7,8-tetramethyl-1,10-phenanthroline, 2, effectively kill cancer cells by triggering necroptosis, a non-apoptotic form of cell death. Both complexes evoke necrosome (RIP1-RIP3)-dependent intracellular reactive oxygen species (ROS) production and propidium iodide uptake. The complexes also induce mitochondrial membrane potential depletion, a possible downstream effect of ROS production. Apparently, 1 and 2 are the first rhenium complexes to evoke cellular events consistent with programmed necrosis in cancer cells. Furthermore, 1 and 2 display low acute toxicity in C57BL/6 mice and reasonable stability in fresh human blood. |
| first_indexed | 2024-09-23T09:55:06Z |
| format | Article |
| id | mit-1721.1/110417 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:55:06Z |
| publishDate | 2017 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1104172022-09-30T17:44:07Z Necroptosis-Inducing Rhenium(V) Oxo Complexes Suntharalingam, Kogularamanan Awuah, Samuel Bruno, Peter Michael Johnstone, Timothy Wang, Fang Lin, Wei Zheng, Yaorong Page, Julia E. Hemann, Michael Lippard, Stephen J. Massachusetts Institute of Technology. Department of Chemistry Koch Institute for Integrative Cancer Research at MIT Suntharalingam, Kogularamanan Awuah, Samuel Bruno, Peter Michael Johnstone, Timothy Wang, Fang Lin, Wei Zheng, Yaorong Page, Julia E. Hemann, Michael Lippard, Stephen J. Rhenium(V) oxo complexes of general formula [ReO(OMe)(N^N)Cl₂], where N^N = 4,7-diphenyl-1,10-phenanthroline, 1, or 3,4,7,8-tetramethyl-1,10-phenanthroline, 2, effectively kill cancer cells by triggering necroptosis, a non-apoptotic form of cell death. Both complexes evoke necrosome (RIP1-RIP3)-dependent intracellular reactive oxygen species (ROS) production and propidium iodide uptake. The complexes also induce mitochondrial membrane potential depletion, a possible downstream effect of ROS production. Apparently, 1 and 2 are the first rhenium complexes to evoke cellular events consistent with programmed necrosis in cancer cells. Furthermore, 1 and 2 display low acute toxicity in C57BL/6 mice and reasonable stability in fresh human blood. National Cancer Institute (U.S.) (CA034992) 2017-07-03T13:47:29Z 2017-07-03T13:47:29Z 2015-02 Article http://purl.org/eprint/type/JournalArticle 0002-7863 1520-5126 http://hdl.handle.net/1721.1/110417 Suntharalingam, Kogularamanan; Awuah, Samuel G.; Bruno, Peter M.; Johnstone, Timothy C.; Wang, Fang; Lin, Wei; Zheng, Yao-Rong; Page, Julia E.; Hemann, Michael T. and Lippard, Stephen J. “Necroptosis-Inducing Rhenium(V) Oxo Complexes.” Journal of the American Chemical Society 137, 8 (March 2015): 2967–2974 © 2015 American Chemical Society https://orcid.org/0000-0002-6958-3991 https://orcid.org/0000-0003-3383-0118 https://orcid.org/0000-0002-9192-6858 https://orcid.org/0000-0002-2693-4982 en_US http://dx.doi.org/10.1021/ja511978y Journal of the American Chemical Society Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Suntharalingam, Kogularamanan Awuah, Samuel Bruno, Peter Michael Johnstone, Timothy Wang, Fang Lin, Wei Zheng, Yaorong Page, Julia E. Hemann, Michael Lippard, Stephen J. Necroptosis-Inducing Rhenium(V) Oxo Complexes |
| title | Necroptosis-Inducing Rhenium(V) Oxo Complexes |
| title_full | Necroptosis-Inducing Rhenium(V) Oxo Complexes |
| title_fullStr | Necroptosis-Inducing Rhenium(V) Oxo Complexes |
| title_full_unstemmed | Necroptosis-Inducing Rhenium(V) Oxo Complexes |
| title_short | Necroptosis-Inducing Rhenium(V) Oxo Complexes |
| title_sort | necroptosis inducing rhenium v oxo complexes |
| url | http://hdl.handle.net/1721.1/110417 https://orcid.org/0000-0002-6958-3991 https://orcid.org/0000-0003-3383-0118 https://orcid.org/0000-0002-9192-6858 https://orcid.org/0000-0002-2693-4982 |
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