A Dual-Targeting, P53-Independent, Apoptosis-Inducing Platinum( Ii ) Anticancer Complex, [Pt(BDI [superscript QQ] )]Cl

A Dual-Targeting, P53-Independent, Apoptosis-Inducing Platinum( Ii ) Anticancer Complex, [Pt(BDI [superscript QQ] )]Cl

The therapeutic index and cellular mechanism of action of [Pt(BDI[superscript QQ])]Cl, a monocationic, square-planar platinum(II) complex, are reported. [Pt(BDI[superscript QQ])]Cl was used to treat several cell lines, including wild type and cisplatin-resistant ovarian carcinoma cells (A2780 and A2...

Full description

Bibliographic Details
Main Authors: Suntharalingam, Kogularamanan, Wilson, Justin Jeff, Lin, Wei, Lippard, Stephen J.
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: Royal Society of Chemistry, The 2017
Online Access:http://hdl.handle.net/1721.1/110426
https://orcid.org/0000-0002-2693-4982

Internet

http://hdl.handle.net/1721.1/110426
https://orcid.org/0000-0002-2693-4982

Similar Items