Manganese Binding Properties of Human Calprotectin under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced Electron Paramagnetic Resonance Spectroscopic Analysis

Manganese Binding Properties of Human Calprotectin under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced Electron Paramagnetic Resonance Spectroscopic Analysis

The antimicrobial protein calprotectin (CP), a hetero-oligomer of the S100 family members S100A8 and S100A9, is the only identified mammalian Mn(II)-sequestering protein. Human CP uses Ca(II) ions to tune its Mn(II) affinity at a biologically unprecedented hexahistidine site that forms at the S100A8...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Gagnon, Derek M., Stich, Troy A., Britt, R. David, Brophy, Megan Brunjes, Bowman, Sarah E. J., Drennan, Catherine L., Nolan, Elizabeth Marie
Awduron Eraill: Massachusetts Institute of Technology. Department of Biology
Fformat: Erthygl
Iaith:en_US
Cyhoeddwyd: American Chemical Society (ACS) 2017
Mynediad Ar-lein:http://hdl.handle.net/1721.1/110432
https://orcid.org/0000-0001-5486-2755
https://orcid.org/0000-0002-6153-8803

Rhyngrwyd

http://hdl.handle.net/1721.1/110432
https://orcid.org/0000-0001-5486-2755
https://orcid.org/0000-0002-6153-8803

Eitemau Tebyg