Transitions in genetic toggle switches driven by dynamic disorder in rate coefficients

In biochemical systems, intrinsic noise may drive the system switch from one stable state to another. We investigate how kinetic switching between stable states in a bistable network is influenced by dynamic disorder, i.e., fluctuations in the rate coefficients. Using the geometric minimum action me...

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Bibliographic Details
Main Authors: Chen, Hang, Thill, Peter Daniel, Cao, Jianshu
Other Authors: Massachusetts Institute of Technology. Department of Chemistry
Format: Article
Language:en_US
Published: American Institute of Physics (AIP) 2017
Online Access:http://hdl.handle.net/1721.1/110439
https://orcid.org/0000-0003-4878-2366
https://orcid.org/0000-0001-6259-8800
https://orcid.org/0000-0001-7616-7809