Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing

Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing

Small cell lung carcinoma (SCLC) is a highly lethal, smoking-associated cancer with few known targetable genetic alterations. Using genome sequencing, we characterized the somatic evolution of a genetically engineered mouse model (GEMM) of SCLC initiated by loss of Trp53 and Rb1. We identified alter...

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Bibliographic Details
Main Authors: Taylor-Weiner, Amaro, Stewart, Chip, Carter, Scott L., Cibulskis, Kristian, McKenna, Aaron, Dooley, Alison, Sougnez, Carrie, Park, Jennifer, Farago, Anna F., Dayton, Talya, Shefler, Erica, Gabriel, Stacey, Getz, Gad, McFadden, David Glenn, Papagiannakopoulos, Thales, Bhutkar, Arjun, Vernon, Amanda, Malstrom, Scott E., Heimann, Megan Kristianne, Parker, Jennifer E., Chen, Frances K., Jacks, Tyler E.
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/110469
https://orcid.org/0000-0001-9587-0233
https://orcid.org/0000-0003-4336-2135
https://orcid.org/0000-0001-5785-8911

Internet

http://hdl.handle.net/1721.1/110469
https://orcid.org/0000-0001-9587-0233
https://orcid.org/0000-0003-4336-2135
https://orcid.org/0000-0001-5785-8911

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