Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

Background A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both tissues. We investigated aggrecan proteolysis patterns in cartil...

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Bibliographic Details
Main Authors: Swärd, Per, Hansson, Maria, Lohmander, L. S, Struglics, André, Lohmander, L. Stefan, Grodzinsky, Alan J., Wang, Yang, Grodzinsky, Alan J
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: BioMed Central Ltd 2017
Online Access:http://hdl.handle.net/1721.1/110583
https://orcid.org/0000-0002-4942-3456

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http://hdl.handle.net/1721.1/110583
https://orcid.org/0000-0002-4942-3456

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