Transcriptome analysis of human ageing in male skin shows mid-life period of variability and central role of NF-κB

Transcriptome analysis of human ageing in male skin shows mid-life period of variability and central role of NF-κB

Age is well-known to be a significant factor in both disease pathology and response to treatment, yet the molecular changes that occur with age in humans remain ill-defined. Here, using transcriptome profiling of healthy human male skin, we demonstrate that there is a period of significantly elevate...

Full description

Bibliographic Details
Main Authors:	Haustead, Daniel J., Stevenson, Andrew, Saxena, Vishal, Marriage, Fiona, Firth, Martin, Silla, Robyn, Martin, Lisa, Adcroft, Katharine F., Rea, Suzanne, Day, Philip J., Melton, Phillip, Wood, Fiona M., Fear, Mark W.
Other Authors:	Massachusetts Institute of Technology. Department of Mechanical Engineering
Format:	Article
Language:	en_US
Published:	Springer Nature 2017
Online Access:	http://hdl.handle.net/1721.1/110863

Similar Items

NF-κB-inducing kinase is dispensable for activation of NF-κB in inflammatory settings but essential for lymphotoxin β receptor activation of NF-κB in primary human fibroblasts
by: Smith, C, et al.
Published: (2001)

Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer
by: Aishat Motolani, et al.
Published: (2020-12-01)

The role of NF-κB in diabetic cardiomyopathy
by: Huang-Jun Liu, et al.
Published: (2024-12-01)

Regulation of pyroptosis by NF-κB signaling
by: Ling Yang, et al.
Published: (2025-01-01)

NFκB and AP-1 Drive Human Myometrial IL8 Expression
by: Shirin Khanjani, et al.
Published: (2012-01-01)

NF-κB Mutations in Germinal Center B-Cell Lymphomas: Relation to NF-κB Function in Normal B Cells
by: Laura Pasqualucci, et al.
Published: (2022-10-01)

NF-κB Fans the Flames of Lung Carcinogenesis
by: Wong, Kwok-Kin, et al.
Published: (2014)

NF-κB Signaling in the Brain of Autistic Subjects
by: Mazhar Malik, et al.
Published: (2011-01-01)

NF-κB signaling pathway in tumor microenvironment
by: Yaning Cao, et al.
Published: (2024-10-01)

TLRs, NF-κB, JNK, and Liver Regeneration
by: Yuji Iimuro, et al.
Published: (2010-01-01)

A mitochondrial checkpoint to NF-κB signaling
by: Emma Guilbaud, et al.
Published: (2024-07-01)

NF-κB in Cancer Immunity: Friend or Foe?
by: Guilhem Lalle, et al.
Published: (2021-02-01)

The Role of APOE and NF-κB in Alzheimer’s Disease
by: Don A. Davies
Published: (2021-10-01)

NF-κB in Gastric Cancer Development and Therapy
by: Supattra Chaithongyot, et al.
Published: (2021-07-01)

Comparison of the Potency of Pterostilbene with NF-κB Inhibitors in Platelet Activation: Mutual Activation by Akt-NF-κB Signaling in Human Platelets
by: Chih-Wei Hsia, et al.
Published: (2021-07-01)

TNF stimulation primarily modulates transcriptional burst size of NF‐κB‐regulated genes
by: Victor L Bass, et al.
Published: (2021-07-01)

High-throughput analysis of NF-κB dynamics in single cells reveals basal nuclear localization of NF-κB and spontaneous activation of oscillations.
by: Samuel Zambrano, et al.
Published: (2014-01-01)

Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin’s lymphoma
by: Martin A. Schumacher, et al.
Published: (2010-01-01)

Examining Guyots in the Mid-Pacific Mountains
by: Firth, J
Published: (1993)

NF-κB Inhibition after Cecal Ligation and Puncture Reduces Sepsis-Associated Lung Injury without Altering Bacterial Host Defense
by: Hui Li, et al.
Published: (2013-01-01)

The NF-κB Genomic Landscape in Lymphoblastoid B Cells
by: Zhao, Bo, et al.
Published: (2016)

The role of ELKS isoforms in leptin and NF-κB signaling.
by: Woo, Yissue.
Published: (2012)

NF-κB as a Target for Modulating Inflammatory Responses.
by: Gasparini, C, et al.
Published: (2012)

NF-κB as a target for modulating inflammatory responses.
by: Gasparini, C, et al.
Published: (2012)

Review of Small Molecule Anticancer NF-κB Inhibitors
by: Sh. R. Kzyrgalin, et al.
Published: (2023-07-01)

ROLE OF NUCLEAR FACTOR NF-κB IN ALLOGRAFT REJEKTION
by: N. V. Kuncevich
Published: (2010-06-01)

Erratum to “NF-κB Signaling in the Brain of Autistic Subjects”
by: Mazhar Malik, et al.
Published: (2013-01-01)

NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis
by: Shin Maeda
Published: (2010-01-01)

Haptoglobin buffers lipopolysaccharides to delay activation of NFκB
by: Laura Zein, et al.
Published: (2024-10-01)

Expression of CYLD and NF-κB in Human Cholesteatoma Epithelium
by: Jae Yong Byun, et al.
Published: (2010-01-01)

Understanding NF‐κB signaling via mathematical modeling
by: Raymond Cheong, et al.
Published: (2008-05-01)

Redox Homeostasis in Poultry: Regulatory Roles of NF-κB
by: Peter F. Surai, et al.
Published: (2021-01-01)

Investigation of Leoligin Derivatives as NF-κΒ Inhibitory Agents
by: Thomas Linder, et al.
Published: (2021-12-01)

The Transcription Factor NF-κB in Stem Cells and Development
by: Christian Kaltschmidt, et al.
Published: (2021-08-01)

A homeostatic model of IκB metabolism to control constitutive NF‐κB activity
by: Ellen L O'Dea, et al.
Published: (2007-05-01)

Protective effects of Boswellia and Curcuma extract on oxaliplatin-induced neuropathy via modulation of NF-κB signaling
by: Sakshi Mahajan, et al.
Published: (2024-12-01)

The Inflammatory Response to Double Stranded DNA in Endothelial Cells Is Mediated by NFκB and TNFα
by: Patel, Suraj J., et al.
Published: (2011)

Targeting NF-κB signaling in macrophages through drug repurposing
by: Roberti, A
Published: (2024)

Helicobacter pylori-induced NF-κB: trailblazer for gastric pathophysiology
by: Maubach, G, et al.
Published: (2022)

Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB
by: Christian Engelmann, et al.
Published: (2016-01-01)