High-throughput mapping of regulatory DNA
Quantifying the effects of cis-regulatory DNA on gene expression is a major challenge. Here, we present the multiplexed editing regulatory assay (MERA), a high-throughput CRISPR-Cas9–based approach that analyzes the functional impact of the regulatory genome in its native context. MERA tiles thousan...
Main Authors: | , , , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2017
|
Online Access: | http://hdl.handle.net/1721.1/110904 https://orcid.org/0000-0001-5809-3041 https://orcid.org/0000-0003-2357-1546 https://orcid.org/0000-0002-5845-748X https://orcid.org/0000-0002-0561-7072 https://orcid.org/0000-0003-1709-4034 |