Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System

Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System

In vitro hepatocyte culture systems have inherent limitations in capturing known human drug toxicities that arise from complex immune responses. Therefore, we established and characterized a liver immunocompetent coculture model and evaluated diclofenac (DCF) metabolic profiles, in vitro–in vivo cle...

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Bibliographic Details
Main Authors: Large, Emma, Hughes, David J., Sarkar, Ujjal, Ravindra, Kodihalli C., Young, Carissa L., Rivera-Burgos, Dinelia, Yu, Jiajie, Cirit, Murat, Wishnok, John S, Lauffenburger, Douglas A, Griffith, Linda G, Tannenbaum, Steven R
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: American Society for Pharmacology & Experimental Therapeutics (ASPET) 2017
Online Access:http://hdl.handle.net/1721.1/110981
https://orcid.org/0000-0002-8581-1261
https://orcid.org/0000-0002-9618-8495
https://orcid.org/0000-0001-6975-5047
https://orcid.org/0000-0002-2325-552X
https://orcid.org/0000-0002-1801-5548

Internet

http://hdl.handle.net/1721.1/110981
https://orcid.org/0000-0002-8581-1261
https://orcid.org/0000-0002-9618-8495
https://orcid.org/0000-0001-6975-5047
https://orcid.org/0000-0002-2325-552X
https://orcid.org/0000-0002-1801-5548

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