Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases

Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We developed a comprehensive resource of 394 cell type– and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity among transcription factors, enhancers, promoter...

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Bibliographic Details
Main Authors: Marbach, Daniel, Lamparter, David, Quon, Gerald, Kellis, Manolis, Kutalik, Zoltán, Bergmann, Sven
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/111077
https://orcid.org/0000-0002-1716-0153