Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases
Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We developed a comprehensive resource of 394 cell type– and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity among transcription factors, enhancers, promoter...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2017
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| Online Access: | http://hdl.handle.net/1721.1/111077 https://orcid.org/0000-0002-1716-0153 |
| _version_ | 1826199708647817216 |
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| author | Marbach, Daniel Lamparter, David Quon, Gerald Kellis, Manolis Kutalik, Zoltán Bergmann, Sven |
| author2 | Broad Institute of MIT and Harvard |
| author_facet | Broad Institute of MIT and Harvard Marbach, Daniel Lamparter, David Quon, Gerald Kellis, Manolis Kutalik, Zoltán Bergmann, Sven |
| author_sort | Marbach, Daniel |
| collection | MIT |
| description | Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We developed a comprehensive resource of 394 cell type– and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity among transcription factors, enhancers, promoters and genes. Integration with 37 genome-wide association studies (GWASs) showed that disease-associated genetic variants—including variants that do not reach genome-wide significance—often perturb regulatory modules that are highly specific to disease-relevant cell types or tissues. Our resource opens the door to systematic analysis of regulatory programs across hundreds of human cell types and tissues |
| first_indexed | 2024-09-23T11:24:26Z |
| format | Article |
| id | mit-1721.1/111077 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:24:26Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1110772022-09-27T19:20:55Z Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases Marbach, Daniel Lamparter, David Quon, Gerald Kellis, Manolis Kutalik, Zoltán Bergmann, Sven Broad Institute of MIT and Harvard Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Quon, Gerald Kellis, Manolis Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We developed a comprehensive resource of 394 cell type– and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity among transcription factors, enhancers, promoters and genes. Integration with 37 genome-wide association studies (GWASs) showed that disease-associated genetic variants—including variants that do not reach genome-wide significance—often perturb regulatory modules that are highly specific to disease-relevant cell types or tissues. Our resource opens the door to systematic analysis of regulatory programs across hundreds of human cell types and tissues 2017-08-31T17:40:05Z 2017-08-31T17:40:05Z 2016-03 2015-07 Article http://purl.org/eprint/type/JournalArticle 1548-7091 1548-7105 http://hdl.handle.net/1721.1/111077 Marbach, Daniel et al. “Tissue-Specific Regulatory Circuits Reveal Variable Modular Perturbations Across Complex Diseases.” Nature Methods 13, 4 (March 2016): 366–370 © 2016 Nature America, Inc https://orcid.org/0000-0002-1716-0153 en_US http://dx.doi.org/10.1038/nmeth.3799 Nature Methods Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Marbach, Daniel Lamparter, David Quon, Gerald Kellis, Manolis Kutalik, Zoltán Bergmann, Sven Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases |
| title | Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases |
| title_full | Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases |
| title_fullStr | Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases |
| title_full_unstemmed | Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases |
| title_short | Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases |
| title_sort | tissue specific regulatory circuits reveal variable modular perturbations across complex diseases |
| url | http://hdl.handle.net/1721.1/111077 https://orcid.org/0000-0002-1716-0153 |
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