Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases
Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We developed a comprehensive resource of 394 cell type– and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity among transcription factors, enhancers, promoter...
Main Authors: | Marbach, Daniel, Lamparter, David, Quon, Gerald, Kellis, Manolis, Kutalik, Zoltán, Bergmann, Sven |
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Other Authors: | Broad Institute of MIT and Harvard |
Format: | Article |
Language: | en_US |
Published: |
Nature Publishing Group
2017
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Online Access: | http://hdl.handle.net/1721.1/111077 https://orcid.org/0000-0002-1716-0153 |
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