Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions

Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions

Massively parallel reporter assays (MPRAs) enable nucleotide-resolution dissection of transcriptional regulatory regions, such as enhancers, but only few regions at a time. Here we present a combined experimental and computational approach, Systematic high-resolution activation and repression profil...

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Bibliographic Details
Main Authors: Ernst, Jason, Melnikov, Alexandre, Zhang, Xiaolan, Wang, Li, Rogov, Peter L, Mikkelsen, Tarjei, Kellis, Manolis
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: Nature Publishing Group 2017
Online Access:http://hdl.handle.net/1721.1/111103

Internet

http://hdl.handle.net/1721.1/111103

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