Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

The prevailing approach to addressing secondary drug resistance in cancer focuses on treating the resistance mechanisms at relapse. However, the dynamic nature of clonal evolution, along with potential fitness costs and cost compensations, may present exploitable vulnerabilities—a notion that we ter...

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Bibliographic Details
Main Authors: Zhao, Boyang, Srinivas, Raja Ram, Creixell Morera, Pau, Tidor, Bruce, Lauffenburger, Douglas A, Hemann, Michael, Pritchard, Justin R.
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/111131
https://orcid.org/0000-0003-4610-1707
https://orcid.org/0000-0002-5476-903X
https://orcid.org/0000-0001-7529-3029
https://orcid.org/0000-0002-3320-3969

Internet

http://hdl.handle.net/1721.1/111131
https://orcid.org/0000-0003-4610-1707
https://orcid.org/0000-0002-5476-903X
https://orcid.org/0000-0001-7529-3029
https://orcid.org/0000-0002-3320-3969

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