A Fungal-Selective Cytochrome bc₁ Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance

A Fungal-Selective Cytochrome bc₁ Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance

To cause disease, a microbial pathogen must adapt to the challenges of its host environment. The leading fungal pathogen Candida albicans colonizes nutrient-poor bodily niches, withstands attack from the immune system, and tolerates treatment with azole antifungals, often evolving resistance. To dis...

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Bibliographic Details
Main Authors: Srinivas, Raja, Lancaster, Alex K., Scherz-Shouval, Ruth, Whitesell, Luke, Vincent, Benjamin Matteson, Langlois, Jean-Baptiste, Tidor, Bruce, Buchwald, Stephen Leffler, Lindquist, Susan
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/111146
https://orcid.org/0000-0002-3320-3969
https://orcid.org/0000-0003-3875-4775
https://orcid.org/0000-0003-1307-882X

Internet

http://hdl.handle.net/1721.1/111146
https://orcid.org/0000-0002-3320-3969
https://orcid.org/0000-0003-3875-4775
https://orcid.org/0000-0003-1307-882X

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