Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis

Genetic screens are powerful tools for identifying genes responsible for diverse phenotypes. Here we describe a genome-wide CRISPR/Cas9-mediated loss-of-function screen in tumor growth and metastasis. We mutagenized a non-metastatic mouse cancer cell line using a genome-scale library with 67,405 sin...

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Bibliographic Details
Main Authors: Lee, Kyungheon, Song, Jun, Weissleder, Ralph, Lee, Hakho, Chen, Sidi, Sanjana, Neville E, Zheng, Kaijie, Shalem, Ophir, Shi, Xi, Scott, David Arthur, Pan, Jennifer Q., Zhang, Feng, Sharp, Phillip A.
Other Authors: Broad Institute of MIT and Harvard
Format: Article
Language:en_US
Published: Elsevier 2017
Online Access:http://hdl.handle.net/1721.1/111184
https://orcid.org/0000-0002-2639-9879
https://orcid.org/0000-0003-2782-2509
https://orcid.org/0000-0003-1465-1691

Internet

http://hdl.handle.net/1721.1/111184
https://orcid.org/0000-0002-2639-9879
https://orcid.org/0000-0003-2782-2509
https://orcid.org/0000-0003-1465-1691

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